PMID:

Citation Count:

207

H5 Index:

n/a

SJR:

n/a

Keywords & Tags:

Anxiety, Animal Trial, CBD, Neuropsychiatric Disorders, anxiolytic, Diazepan, elevated plus-maze model of anxiety

Participants:

n/a

Dosage:

2.5, 5.0, 10.0 and 20.0 mg/kg

Duration:

n/a

Route:

Oral

Highlights & Conclusions:

In order to assess the presence of anxiolytic properties in cannabidiol (CBD) the drug was tested in an elevated plus-maze model of anxiety, in rats. Doses of 2.5, 5.0 and 10.0 mg/kg significantly increased the entry ratio (open/total number of entries), an anxiolytic-like effect. CBD at a dose of 20.0 mg/kg was no longer effective. None of the doses of CBD used changed total number of entries, a measure of total exploratory activity. Diazepam (2.0 mg/kg) also caused an anxiolytic-like effect in this model. These results indicate that CBD causes a selective anxiolytic effect in the elevated plus-maze, within a limited range of doses.